Page 26 - CatalogNEP-LS

LEARNING OUTCOMES:

This course will enable the students to understand:
 About inheritance of qualitative and quantitative traits, allelic and genotypic frequencies, and
their partitioning between and among populations.
 Elucidate factors governing the genetic structure of populations: significance, implications,
and applications.
 Will enable to learn about- mapping genes in bacteria, functional allelism, gene regulation in
prokaryotes: the components and the mechanisms.
 Provide knowledge about the use of linkage and recombination frequencies to map genes,
molecular markers, types, development, and applications

THEORY(45 Hours)

UNIT-I: (12 Hours)
Introduction to Genetics and Heredity: Mendel'swork on transmission of traits, Principles of
inheritance, Chromosome theory of inheritance, Incomplete dominance and co-
dominance,Multiplealleles,Lethalalleles,Epistasis,Pleiotropy,Molecular basis of Genetic
Information.

UNIT-II: (15 Hours)
Mutations and Chromosomal Aberrations: Chromosomal Mutations: Deletion, Duplication,
Inversion, Translocation, Aneuploidy and Polyploidy; Gene mutations: Induced versus
Spontaneous mutations, Back versus Suppressor mutations; structural and numerical alteration of
chromosomes.

UNIT-III: (12 Hours)
Linkage, Crossing Over, Chromosomal Mapping and Human Genetics: Linkage, crossing over;
one, two or three point crossovers, chromosomal mapping, Interference and coincidence,
chromosomal and genetic disorders; genetic code and Wobble‘s hypothesis.
UNIT-IV: (6 Hours)

Sex Determination: Chromosomal mechanisms, sex linkedinheritance, extra-chromosomal
inheritance, dosage compensation.

PRACTICAL (30 Hours)

1. Study of Linkage, recombination, gene mapping using charts.
2. Meiosis through temporary squash preparation.
3. Mendel‘s laws through seed ratios. Laboratory exercises in probability and chi-square.
Chromosome mapping using point test cross data.
4. Pedigree analysis for dominant and recessive autosomal and sex-linked traits.
5. Incomplete dominance and gene interaction through seed ratios (9:7, 9:6:1, 13:3, 15:1, 12:3:1,
9:3:4).
6. Blood Typing: ABO groups & Rh factor. Study of aneuploidy: Down‘s, Klinefelter‘s and
Turner‘s syndromes.
7. Photographs/Permanent Slides showing Translocation Ring, Laggards and Inversion Bridge.

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