Page 117 - CatalogNEP-PS

5. Vincent Alan, Molecular Symmetry and Group theory A programmed introduction to
Chemical Applications, Pubs:John Wiley & Sons Ltd., 1977 (Reprint 1998).
6. Cotton F. A.,Chemical applications of group theory, 3 rd Edition, Pubs: John Wiley New
York, 1971 [Indian print by Wiley Eastern, 1999].
7. Jaffe H. H. and Orchin M., Symmetry in Chemistry, Pubs: John Wiley New York, 1965.
8. Stout G.H. and Jeansen L.H., X-ray structure determination a practical guide, Pubs: John
Wiley & Sons, New York (1989).
9. Glusker J.P., Lewis M, Crystal structure analysis for chemists and biologists, Pubs: VCH
Publisher inc., New York (1994).
10. Steed J. W. and Atwood J. L., Supramolecular Chemistry, John Wiley and Sons, Ltd, (2000)
11. A text Book of Quantitative Inorganic Analysis: A.I. Vogal.
12. Commercial Methods of Analysis: Shell & Biffen

Chem.412 Chemistry of Natural Products 3+1

LEARNING OBJECTIVES:

Objectives of this course are:
 to familiarize the students about different classes of natural products.
 to provide basic knowledge about applications of natural products and their derivatives.

LEARNING OUTCOMES:

The student will be able to
 to synthesize different kinds of compounds.
 to apply the study of natural products to prepare different derivatives.

THEORY (45 Hours)

UNIT-I Terpenoids and Carotenoids (11 Hours)

Classification, occurrence, isolation, general methods of structure determination. Biosynthesis
and synthesis of citral, geraniol, α -terpineol, menthol, farnesol, zingiberene, santonine,
longifolene, abietic acid, and vitamin A. Plant Pigments Occurrence, nomenclature, synthesis of
Quercetin myrcetin cyanidine hirsutidin
UNIT-II Steroids (11 Hours)

Occurrence, basic skeleton, stereochemistry, structure determination of cholesterol by degradation
experiments, synthesis and biosynthesis of cholesterol, bile acids, and testosterone,
estrone(Vollhardt Synthesis), progesterone( Johnsons Synthesis), vitamin D, cortisone.

UNIT-III Alkaloids (11 Hours)
Occurrence, isolation, general method structure elucidtion, degradation, classification based on
nitrogen heterocyclic ring structure, stereochemistry andsynthesis of ephedrine, Nicotine,
atropine, quinine (Woodward and Storks synthesis), morphine, (±) Strychnine*, chloroquin and
primaquin

UNIT-IV Vitamins (12 Hours)

Occurrence, deficiency, physiological effects and synthesis of B complex, E and K.
Chemotherapy Antibiotics: General structure determination/elucidation of penicillin and
terramycin. Synthesis of penicillin G and V (via APA). Introduction to the structure and function
of antibiotics i.e. ampicillin, amoxycillin, chloramphenicol, cephalosporin, tetracycline and
streptomycin. Mode of action of antibacterial agents. Sulpha drugs Prostaglandins Biosynthesis,
Synthesis of PGE2 and PGF2α.

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