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1.  Atkins P.W. and Friedman R.S., Molecular Quantum Mechanics, 4th edition, Pubs: Oxford
                    University Press, (2004).
                 2.  McQuarrie D., Quantum Chemistry, 2nd edition, Pubs: University Science Books (2008).
                 3.  Levine I.N., Quantum Chemistry, 5th edition, Pubs: Prentice Hall (2006).
                 4.  Kreyszig E., Advanced Engineering Mathematics, Pubs: John Wiley, NY (2001).
                 5.  Ayres F.Jr., Matrics, Pubs. McGraw Hill, New Delhi (1974).
                 6.  Pilar F.L., Elementary Quantum Chemistry, Pubs:McGraw Hill (1968).
                 7.  March N.H., Self-Consistent Fields in Atoms, Pubs:Pergamon Press (1975).
                 8.  Chandra A.K., Introductory Quantum Chemistry, Pubs: Tata-McGraw Hill(1988).
                 9.  Pople J.A. and Beveridge D.L., Approximate Molecular-Orbital Theory, Pubs: McGraw Hill,
                    NY (1970).
                 10.  Lowe J.P., Quantum Chemistry, Pubs: Academic Press (1993).
                 11.  Senior Practical Physical Chemistry: B.D. Khosla, V.C. Garg and A. Khosla
                 12.  Experimental Physical Chemistry: V. Athawale and P. Mathur.


               Chem.421                  Bioinorganic Chemistry                                          3+1


               LEARNING OBJECTIVES:

               Objectives of this course are:
                     to provide deep insights into the chemistry of biological systems.
                     to explain the role of metals in chemical reactions involved in these systems.


               LEARNING OUTCOMES:

               The student will be able to
                     to  understand  the  processes  associated  with  heme  and  non-heme  proteins,  iron-sulphur
                       proteins, and their role in biological systems.
                     to  have  an  insight  into  the  role  of  metals  in  the  functioning  of  some  enzymes  and  in
                       nitrogen fixation.

               THEORY (45 Hours)
               UNIT- I:                                                                           (11 Hours)

               Elementary  Cell  Biology:  Introduction  to  biomolecules:  proteins,  enzymes,  nucleic  acids,
               porphyrin and corrins. Role of metals in bio-systems: a general survey of the role of main group
               elements  and  transition  elements  in  biological  systems  ionophores,  cation  transport:  Na/K  ion
               pump.  Heme  and  non-heme  proteins,  Haemoglobin  and  myoglobin  as  oxygen  carriers,  Bohr
               effect. Coordination chemistry of Fe(II) in haemoglobin and oxyhaemoglobin. Relaxed and tense
               (R & T) configurations of haemoglobin, electronic formulations and mode of bonding of dioxygen
               in haemoglobin (modeling), Cytochromes and other natural oxygen carriers such as hemerythrins
               and hemocyanins. (iv) Iron sulphur proteins and electron transfer agents in biological systems:
               Systems, synthetic models of 4-fe ferredoxins. (v) Iron supply and transport in biological systems:
               Ferritin, transferrin and siderophores.

               UNIT-II:                                                                           (12 Hours)
               Bio-inorganic  chemistry  of  cobalt,  vitamin  B12,  cobalamins,  cobamides  and  their  model
               compounds. Redox chemistry of B12, mechanisms of reactions catalysed B12 dependent enzymes
               and model compounds of B12.Role of Metals in Medicine: Metal deficiency and disease, toxic
               effects  of  metals,  metals  used  for  diagnosis  and  chemotherapy  with  particular  reference  to



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