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atropine, quinine (Woodward and Storks synthesis), morphine, (±) Strychnine*, chloroquin and
primaquin
UNIT-IV Vitamins (12 Hours)

Occurrence, deficiency, physiological effects and synthesis of B complex, E and K.
Chemotherapy Antibiotics: General structure determination/elucidation of penicillin and
terramycin. Synthesis of penicillin G and V (via APA). Introduction to the structure and function
of antibiotics i.e. ampicillin, amoxycillin, chloramphenicol, cephalosporin, tetracycline and
streptomycin. Mode of action of antibacterial agents. Sulpha drugs Prostaglandins Biosynthesis,
Synthesis of PGE2 and PGF2α.

PRACTICAL (30 Hours)

1. Qualitative Analysis: Separation, purification, and identification of binary mixture of
organic compounds by chemical tests.
2. Organic Synthesis:
Acetylation: - Acetylation of cholesterol and separation of cholesteryl acetate by column
chromatography.
Oxidation: Adipic acid by chromic acid oxidation of cyclohexanol.
Grignard reaction: Synthesis of triphenyl methanol from benzoic acid.
Aldol condensation: Dibenzal acetone from benzaldehyde.

SUGGUESTED READINGS:

1. Finar l. L, Organic Chemistry, Vol.1, 2, Pubs: ELBS (1994).
2. Nicolaou K.C. and Sorensen E.J., Classics in Total Synthesis, Pubs: VCHN.Y.(1986).
3. Nicolaou K.C. and Synder, S.A.Classics in Total Synthesis II, Pubs: VCH N.Y.(2003).
4. Akhrem, A.A.Total Steroids Synthesis, Pubs: Plenum Press, New York, (1970)
5. Solomon T.W.G. and Fryhle C.B., Organic Chemistry, 7thEdn., Pubs: John. Wiley & Sons
Inc. N.Y. (2000).
6. Manitto P., Biosynthesis of Natural Products, Pubs: Horwood Ltd.(1981).
7. Padwa, A. Org. Lett. 2007, 9(2), 279-282
8. Macroscale and Microscale Organic Experiments, K.L. Williamson, D.C.Heath.
9. Systematic Qualitative Organic Analysis, H.Middleton, Adward Arnold.
10. Handbook of Organic Analysis-Qualitative and Quantitative, H.Clark, Adward Arnold.
11. Vogel‘s Textbook of Practical Organic Chemistry, A.R. Tatchell, John Wiley.
12. Experiments and Techniques in Organic Chemistry, D.Pasto, C. Johnson and M.Miller,
Prentice Hall.

Chem.413 Statistical Thermodynamics and Quantum Chemistry 3+1

LEARNING OBJECTIVES:

Objectives of this course are:
 to teach the fundamental concepts of statistical thermodynamics and quantum chemistry.
 to provide basic knowledge about applications of quantum chemistry

LEARNING OUTCOMES:

The student will be able to

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