VPT-607    CHEMOTHERAPY    (2+1)

OBJECTIVE

To study the recent advances of chemotherapeutic agents with relevance to pharmacological and therapeutic aspects.

THEORY

UNIT I

General consideration and principles of chemotherapy, classification of chemotherapeutic agents; development of microbial resistance to antimicrobials, combination therapy.

UNIT II

Systemic and gut acting sulfonamides, diaminopyrimidines, quinolones sulfones, nitrofurans.

UNIT III

Penicillins, cephalosporins, beta-lactam antibiotics.

UNIT IV

Chloramphenicol, tetracyclines, macrolides, polymixins, polypeptides.

UNIT V

Aminoglycosides and other antibiotics.

UNIT VI

Anti-protozoans, anthelmintics, ectoparasiticides.

UNIT VII

Antituberculosis, antifungal, antiviral and antineoplastic drugs.

PRACTICAL

General methods for assay of chemotherapeutic agents, antibiotic sensitivity tests, estimation of sulfonamides, penicillins, oxytetracyclines,  trimethoprim and nitrofurans in biological fluids to study their kinetics and bioavailability.

 

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