VPT-601    GENERAL PHARMACOLOGY    (2+0)

OBJECTIVE

To study the scope of pharmacology and to understand the basic mechanisms of drug actions and its effects.

THEORY

UNIT I

History and scope of pharmacology, Principles of drug absorption, distribution, metabolism and elimination. Drug bioavailability and routes of administration.

UNIT II

Important pharmacokinetic parameters and their clinical significance.

UNIT III

Pharmacodynamics: mechanism of action and the relationship between drug concentration and effect; signal transduction mechanism and drug receptors for physiological regulatory molecules.

UNIT IV

Quantitation of drug-receptor interactions and elicited effects. Competitive and non-competitive antagonism. Factors affecting drug response. Adverse drug reactions.

 

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