Page 96 - CatalogNEP-LS

3. Harris, D. C. (2007), Quantitative Chemical Analysis, 6th Edition, Freeman
4. Mikes, O. (2000), Laboratory Handbook of Chromatographic methods, D.Van Nostrand
Company Inc.

Chem.223 Organometallics, Heterocyclic and Polynuclear Hydrocarbons 3+1

LEARNING OBJECTIVES:

The learning objectives of this course are as follows:

 To make the students learn about organometallic compounds, an interface between organic
and inorganic chemistry.
 To learn about polynuclear hydrocarbons and heterocyclic compounds.

LEARNING OUTCOMES:

By the end of this course, students will be able to:
 Identify the different kinds of organometallic compounds, their structures and nature of
bonding.
 Compare the stability of different compounds including metal carbonyls.
 Learn about relative stability, reactivity, and aromatic character of polynuclear hydrocarbons
and heterocyclic compounds.

THEORY (45 Hours)

UNIT-I: (10 Hours)
Organometllic Compounds: Definition and Classification with appropriate examples based on
nature of metal- carbon bond (ionic, s, p and multicentre bonds). Structures of methyl lithium,
Zeiss salt and ferrocene. EAN rule as applied to carbonyls. Preparation, structure, bonding, and
properties of mononuclear and polynuclear carbonyls of 3d metals. p-acceptor behaviour of
carbon monoxide. Synergic effects (VB approach).
UNIT-II: (12 Hours)

Heterocyclic Compounds: Introduction to molecular orbital picture and aromatic characteristics
of furan, pyrrole, thiophene, and pyridine.methods of synthesis and chemical reactions ( mainly
electrophilic substitution with mechanism). mechanism of nucleophilic substitution reactions in
pyridine derivatives.comparison of basicity of pyridine, piperidine and pyrrole.

UNIT-III: (12 Hours)
Introduction to condensed five and six membered heterocyclic compounds. Preparation and
reactions of indole, quinoline and isoquinoline with special reference to Fischer Indole synthesis,
Skraup synthesis and Bischler – Napieralski synthesis. Mechanism of electrophilic substitution
reactions of Indole, Quinoline and Isoquinoline.

UNIT-IV: (6 Hours)
Polynuclear and heteronuclear aromatic compounds: Properties of the following compounds with
reference to electrophilic and nucleophilic substitution: Naphthalene, Anthracene, Furan, Pyrrole,
Thiophene, and Pyridine.
UNIT-V: (5Hours)

81