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anticancer drugs, selenium and tellurium drugs, cis-platin and analogues, alternatives to cis-platin,
adverse effects of anticancer drugs, toxicity due to non-essential metals.
UNIT-III (11Hours)

Metalloenzymes and photosynthesis Metalloenzymes: Carbonic anhydrase and carboxy peptidase,
amino peptidase, Alkaline phosphate. Superoxide dismutase; inhibition of metalloenzymes.
Photosynthesis: Chloropphyll in photosynthesis, current hpothesis for the photo oxidation of
chlorophyl, synthetic leaf, ‗Z‘ diagram for electron transport in PS-I and PS-II photosystem.
Model studies of WOC and Photosystems.
UNIT-IV (11 Hours)

Nitrogen fixation: Classification of nitrogen fixing bacteria. Nitrogenase enzymes: EXAFS
(Extended X-ray absorption fine structure spectroscopy) for characterization of the cofactor of
nitrogenase and its synthetic analogues-double cubane cluster. Vanadium containing nitrogenases,
mechanism of nitrogen fixation by nitrogenases and role of ATP in nitrogen fixation. nitrite
reductase and nitrate reductase.

PRACTICAL (30 Hours)

1. Analysis of mixtures by gravimetric and volumetric methods from the mixture
solutions:
Copper- Nickel
Copper -Magnesium
Copper-Zinc
Iron-Magnesium
Silver-Zinc
Copper-Nickel-Zinc
Fe(II)-Fe(III)
2. Green methods of Preparation of the following:
Bis(acetylacetonato)copper(II)
Tris(acetylacetonato)iron(III)
Tris(acetylacetonato)manganese(III)

SUGGUESTED READINGS:

1. Purcell K.F. and Kotz J.C., Inorganic Chemistry, Pubs: W.B. Saunders & Co., London
(1977).
2. Jolly W.L., Modern Inorganic Chemistry, Pubs: W.B. Saunders & Co., London (1984).
3. Cotton F.A. and Wilkinson G, Advanced Inorganic Chemistry, 5 th Edition, Pubs:Willey
Eastern (1989).
4. Hughes M.N., Inorganic Chemistry of Biological Processes, Pubs: Willey (1972).
5. Dennis, Brown G., Chemistry of Vitamin B-12 and Related Inorganic Model, Systems,
Progress in Inorganic Chemistry (Vol.18)

Chem.422 Pericyclic and Asymmetric Synthesis 3+1

LEARNING OBJECTIVES:

Objectives of this course are:

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