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Zoo.221 Animal Genetics 3+1

LEARNING OBJECTIVES:

The primary objective of this course is:
 To apprise students with the basic principles of Genetics and Molecular Biology and its
applications in living systems

LEARNING OUTCOMES:

This course will enable the students to understand:
 understand the fundamentals of Mendelian inheritance and non-Mendelian inheritance.
describe the concepts of linkage and crossing over and their usage in constructing genetic
maps.
 gain knowledge about chromosomal aberrations and mutations.
 become familiar with structure and function of nucleic acids with reference to replication,
transcription and translation.

THEORY(45 Hours)

UNIT-I: (12Hours)
Mendel‘s principles of inheritance; chromosomal theory of inheritance; incomplete dominance
and co-dominance; multiple allelism; lethal alleles (dominant and recessive lethals); deviations of
Mendelian dihybrid ratio (Epistatic interactions-Dominant, Recessive, Duplicate Dominant,
Duplicate Recessive, Duplicate Gene Interaction, Dominant - Recessive); polygenic inheritance;
numericals based on above; extrachromosomal inheritance (Chloroplast Inheritance: Variation in
Four O` clock plant; Mitochondrial inheritance: petite mutants in yeast); Maternal effect (shell
coiling in snails).
UNIT-II: (15 Hours)

Classical and molecular concept of gene Mutations and Chromosomal Aberrations: Chromosomal
Mutations: Deletion, Duplication, Inversion, Translocation, Aneuploidy and Polyploidy; Gene
mutations: Induced versus Spontaneous mutations, Back versus Suppressor mutations; structural
and numerical alteration of chromosomes,Central Dogma.
UNIT-III: (12 Hours)

Linkage, Crossing Over, Chromosomal Mapping and Human Genetics: Linkage, crossing over;
one, two or three point crossovers, chromosomal mapping, Interference and coincidence,
chromosomal and genetic disorders; genetic code and Wobble‘s hypothesis, sex linkage (eye color
in Drosophila; colour blindness and haemophilia in humans, dosage compensation.
UNIT-IV: (6 Hours)

Haploidy, polyploidy, autopolyploidy (examples: banana, watermelon), allopolyploidy (ancestry
of wheat) and aneuploidy (Down‘s, Turner‘s and Klinefelter‘s syndromes); Deletion; Duplication
(Bar eye in Drosophila); Inversion (paracentric and pericentric); Translocation (Rhoeo,
Oenothera; Robertsonian translocation, Familial Down Syndrome and cancer).

PRACTICAL (30 Hours)

1. Study of Linkage, recombination, gene mapping using charts.

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